Jasvir Kaur said
Is there much in the way of human research on athletic populations though?
To be honest, studies on ecdysterone in vivo (in the body) - no. However, that'll be changing soon. What we do have is plenty of anecdotal feedback over decades of properly dosed, quality extracts and the merits they impart. While I'm a firm believer it works well in humans, I took the additional steps to ensure Ecdy was supported by ingredients like EAA's, of which there are MANY studies supporting safety and efficacy in humans. This, in an effort to make Synthagen "failsafe" for users.
You can find PLENTY of positive feedback with respect to standalone Ecdy of various sorts. Synthagen just takes this to a new level. Specifically, RCE has the ability to speed up the activity of the muscle cell cytoplasm/ribosome - leading to an accelerated rate of Translation and Translocation (1,2). As well, a recent study showed that "Ecdy elicited a rapid elevation in intracellular calcium, followed by sustained Akt activation and increased protein synthesis" (3). It allows for an increase in both the number and activity of ribonucleic acids and the forming of new contractile muscle proteins from available amino acids.
It therefore made all the sense in the world to me, to include both in Synthagen such that they're available at the right time. And like many things in life, success often correlates strongly with timing...
(1) Syrov VN. Mechanism of the anabolic action of phytoecdysteroids in mammals. Nauchnye Doki Vyss Shkoly Biol Nauki (11), (1984): pages 16-20.
(2) N. Todorov, et al. MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTIONTHE EFFECT OF ECDYSTERONE ON THE BIOSYNTHESIS OF PROTEINS AND NUCLEIC ACIDS IN MICE. Translated from Khimiko-Farmatsevticheskii Zhurnal, 34 (9), (Sep. 2000): pages 3-5.
(3) Steroids 2010;75:632 637 - Gorelick-Feldman J, Cohick W, Raskin I. Ecdysteroids elicit a rapid Ca2+ ux leading to Akt activation and increased protein synthesis in skeletal muscle cells.