IMO, the answer is yes. Some color on that now...
The most important consideration is you observe the law of progressive resistance. Overload is the physiological trigger for muscle growth. No overload and there is no reason (nor supplement) that'll cause the body to grow muscle. Another topic for another time..
The most powerful strategy for maxing out your genetic limits is overfeeding during your prime hormonal years. Yet, you can only consume so much (quality) food each day. To this, intra-workout supplementation is the ONE area where supps can act like drugs. You read that right, they can have a drug like impact and it is HERE - where you can take things "farther". This given the fact we know blood flow is elevated up to 400%, insulin etc can be positively modulated and certain nutraceuticals (i.e. Essential Amino Acids) can be more effectively delivered to the muscle.
BOTTOM LINE
Home-made high calorie drinks OR some of the newer generation mass gainers (http://www.predatornutrition.com/en/mass.....ainz-10lb/) can be of value here, allowing you to consume concentrated levels of superior proteins, carbs and performance fats vs. whole foods. Given they digest faster than whole foods, you can consume/assimilate more "caloric cement" during any given time period (day/week/month) than you otherwise could.
Intra-workout, it doesn't get any better than Mass Pro Synthagen - http://www.predatornutrition.com/en/mass.....-270-caps/. Simply put, training with and without it is like night and day for virtually everyone who's tried it.
Hope that helps..